MicroRNAs Involved in Oxidative Stress Processes Regulating Physiological and Pathological Responses

Area of Science:

• Biochemistry
• Molecular Biology
• Cell Biology

Background:

• Oxidative stress impacts cellular functions like differentiation, proliferation, and apoptosis.
• It is implicated in the pathogenesis of numerous diseases, including neurodegenerative disorders and cardiovascular conditions.

Purpose of the Study:

• To review the role of microRNAs (miRNAs) in oxidative stress.
• To explore miRNA regulatory mechanisms and their functions in antioxidant genes.

Main Methods:

• Literature review of studies on miRNAs, oxidative stress, and related diseases.
• Analysis of miRNA regulatory mechanisms, including Keap1-Nrf2 complex interactions.
• Summary of miRNA functions in antioxidant gene regulation.

Main Results:

• miRNAs are involved in diseases driven by oxidative stress.
• Specific miRNAs regulate reactive oxygen species and antioxidant genes.
• miRNA regulatory mechanisms, such as Keap1-Nrf2 uncoupling, are detailed.

Conclusions:

• miRNAs are critical regulators in oxidative stress pathways.
• Understanding miRNA-oxidative stress interactions is vital for developing novel therapeutic strategies for immune diseases.