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Cardiac MRI findings in patients with Crohn's disease

Ibrahim Hasbey1, Furkan Ufuk2, Furkan Kaya3

  • 1Department of Radiology, University of Pamukkale, Kinikli, 20100, Turkey.

Irish Journal of Medical Science
|July 19, 2021
PubMed

Insights

Patients with Crohn's disease (CD) show signs of cardiac involvement, including higher left ventricle extracellular volume and prolonged T2-relaxation times, detectable by cardiac MRI. This suggests inflammation impacts the heart, even if not visually apparent.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Radiology

Background:

  • Crohn's disease (CD) is linked to higher early cardiac death rates compared to the general population.
  • The underlying causes of cardiac complications in CD remain largely unknown.
  • Investigating subclinical cardiac involvement is crucial for understanding CD-related mortality.

Purpose of the Study:

  • To utilize cardiac magnetic resonance imaging (MRI) to identify cardiac findings in CD patients.
  • To compare cardiac MRI results between CD patients and healthy controls (HCs).
  • To assess the potential for cardiac involvement in CD using advanced MRI techniques.

Main Methods:

  • A prospective study involving 20 CD patients and 20 HCs.
  • Cardiac MRI was performed on all participants.
  • Analysis included ventricular function, morphology, myocardial T1/T2-relaxation times, and hematocrit-corrected left ventricle extracellular volume (LV-ECV).

Main Results:

  • CD patients exhibited significantly higher LV-ECV and prolonged T2-relaxation times compared to HCs.
  • Right ventricle ejection fraction was mildly decreased in CD patients.
  • Higher maximum and mean T2-relaxation times were observed in CD patients, correlating with erythrocyte sedimentation rate (ESR).

Conclusions:

  • Cardiac MRI reveals visually undetectable myocardial involvement in CD patients, likely due to chronic systemic inflammation.
  • Cardiac MRI serves as a valuable tool for assessing and monitoring cardiac status in individuals with Crohn's disease.
Abstract

Keywords:
Cardiac edemaCrohn’s diseaseMagnetic resonance imagingMyocardial diseasesParametric mapping

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