Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Giant Lattice Expansion through Structural Frustration Release in a Dense Oxide.

Journal of the American Chemical Society·2026

Same author

Specific Ion Effects in the Near-Surface Molecular Orientation and Surface Coverage of Water.

The journal of physical chemistry letters·2026

Same author

Dynamics of Solvating Water As a Probe of Polymers and Supramolecular Structures.

Chemical reviews·2026

Same author

A Facile and Efficient Route to Achieve Polythiophene-Based Nanoparticles With Various Morphologies.

Angewandte Chemie (International ed. in English)·2025

Same author

APPRAISE: A Tool for Appraising Potential for Bias in Real-World Evidence Studies on Medication Effectiveness or Safety.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2025

Same author

Fibrous polyisocyanide hydrogels for 3D cell culture applications.

Nature protocols·2025

Search research articles

Related Experiment Video

Updated: Oct 27, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Structure and Dynamics of a Temperature-Sensitive Hydrogel.

Eliane P van Dam¹, Hongbo Yuan^2,3, Paul H J Kouwer³

¹AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands.

The Journal of Physical Chemistry. B

|July 19, 2021

Summary

Polyisocyanotripeptides (TriPIC) form thermoresponsive hydrogels. Their side chains trap water, facilitating polymer bundling and gelation.

More Related Videos

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Related Experiment Videos

Last Updated: Oct 27, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Area of Science:

Biomimetic polymers
Polymer science
Hydrogel formation

Background:

Polyisocyanotripeptides (TriPIC) are biomimetic polymers with a β-helical backbone.
Aqueous TriPIC solutions exhibit thermoresponsive behavior, forming hydrogels at 50 °C due to oligoethylene glycol side chains.

Purpose of the Study:

To investigate the molecular structure and water dynamics of TriPIC solutions during gelation.
To elucidate the role of oligoethylene glycol side chains and water interactions in hydrogel formation.

Main Methods:

Fourier Transform Infrared (FT-IR) spectroscopy.
Polarization-resolved femtosecond infrared spectroscopy (fs-IR).

Main Results:

Evidence suggests oligoethylene glycol side chains trap water molecules during gelation.
Observed water trapping indicates a crucial role for side chain-water interactions in polymer bundling.

Conclusions:

The interaction between oligoethylene glycol side chains and water is essential for TriPIC polymer bundling.
This interaction is proposed as the key mechanism driving hydrogel formation in aqueous TriPIC solutions.