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Lactobacillus paracasei HY7015 Promotes Hair Growth in a Telogenic Mouse Model
Woo Nam1, Hyeonji Kim1, Chuhyun Bae1
1R&D Center, Korea Yakult Co. Ltd., Yongin, Korea.
Abstract:
In this study, we describe the effects of Lactobacillus paracasei HY7015 (HY7015) on promoting mouse hair growth. Since our purpose was to increase hair growth through oral administration, medicinal yeast, at a suitable concentration for application in mice, was used as a positive control. First, experiments were conducted to determine the effect of HY7015 on proliferation of hair follicle dermal papilla cells (HFDPC), which are important contributors to hair growth. HY7015 stimulated HFDPC proliferation in vitro and increased their secretion of vascular endothelial growth factor and insulin-like growth factor-1. In mouse experiments, oral administration of HY7015 promoted hair growth and hair follicle maturation in the dorsal skin, as well as increasing growth factor levels in mouse serum. In summary, we demonstrate that L. paracasei HY7015 consumption can promote hair growth by stimulating HFDPC proliferation and growth factor secretion. Follow-up studies are warranted to determine the underlying mechanism, using various approaches, including investigation of changes in intestinal microbiota and alteration of gene and protein expression.
Insights
Lactobacillus paracasei HY7015 (HY7015) promotes mouse hair growth by stimulating dermal papilla cells and increasing growth factors. This probiotic may offer a novel approach to enhancing hair growth.
Area of Science:
- Microbiology
- Dermatology
- Cell Biology
Background:
- Hair follicle dermal papilla cells (HFDPC) are crucial for hair growth.
- Oral administration of probiotics is being explored for various health benefits.
- Lactobacillus paracasei HY7015 (HY7015) is a specific bacterial strain with potential bioactivities.
Purpose of the Study:
- To investigate the effects of Lactobacillus paracasei HY7015 (HY7015) on promoting hair growth.
- To determine if HY7015 influences the proliferation and function of hair follicle dermal papilla cells (HFDPC).
- To assess the impact of oral HY7015 administration on hair growth and related biomarkers in mice.
Main Methods:
- In vitro studies on HFDPC proliferation and growth factor secretion.
- In vivo experiments involving oral administration of HY7015 to mice.
- Assessment of hair growth, hair follicle maturation, and serum growth factor levels.
Main Results:
- HY7015 significantly stimulated HFDPC proliferation in vitro.
- HY7015 increased the secretion of vascular endothelial growth factor and insulin-like growth factor-1 from HFDPC.
- Oral administration of HY7015 promoted hair growth and hair follicle maturation in mice, with elevated serum growth factor levels.
Conclusions:
- Lactobacillus paracasei HY7015 (HY7015) demonstrates potential as a promoter of hair growth.
- HY7015 appears to enhance hair growth by stimulating HFDPC proliferation and growth factor production.
- Further research is needed to elucidate the precise mechanisms, including effects on gut microbiota and gene expression.
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