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Updated: Oct 27, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

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Inflammation Markers in Infants of Mothers with Gestational Diabetes

Emre Dincer1, Sevilay Topçuoğlu1, Didem Arman1

  • 1Neonatal Intensive Care Unit, Health Sciences University, Istanbul Zeynep Kamil Maternity and Children's Hospital Research and Training Hospital, Üsküdar Istanbul, Turkey.

Fetal and Pediatric Pathology
|July 19, 2021
PubMed

AimPentraxin-3, high sensitive CRP (HsCRP) and adropin were investigated in cord blood of infants of mothers with gestational diabetes mellitus (IDM) to evaluate the exposure of fetus to inflammation and whether there is any correlation with clinical findings.MethodsForty IDM and forty three infants whose mother did not have diabetes were included in this prospective study. Adropin, pentraxin-3 and HsCRP levels were measured in the cord blood samples. Echocardiographic measurements were performed in the first three days of life.ResultsAdropin and pentraxine-3 levels were significantly lower and HsCRP levels were significantly higher in IDM group. Echocardiographic measurements of myocardial hypertrophy were negatively correlated with adropin.ConclusionAlterations in these markers in IDM supports the hypothesis of in utero fetal exposure to inflammation caused by gestational diabetes mellitus. Potentially, cord blood adropin might be used as a predictor for complications of diabetes.

Keywords:
Gestational diabetesadropinhigh sensitive CRPnewbornpentraxine-3

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