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Related Experiment Video

Updated: Oct 27, 2025

Author Spotlight: Advancements in Multichannel Extracellular Recording for Studying Neuronal Activity in Freely Moving Mice
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SpikeOnChip : A Custom Embedded Platform for Neuronal Activity Recording and Analysis.

Rick Wertenbroek, Yann Thoma, Flavio Maurizio Mor

    IEEE Transactions on Biomedical Circuits and Systems
    |July 19, 2021
    PubMed
    Summary

    SpikeOnChip enables real-time analysis of neuronal activity from human stem cell-derived neural tissue. This custom platform facilitates automated drug testing by processing electrophysiological data from up to 256 electrodes efficiently.

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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Toxicology

    Background:

    • Automated drug testing and toxicology assessments require advanced tools for analyzing neural tissue.
    • Existing systems may lack the capacity for real-time, high-density electrophysiological data processing.
    • Human induced pluripotent stem cells offer a relevant model for studying neural responses.

    Purpose of the Study:

    • To develop a custom embedded platform, SpikeOnChip, for neuronal activity recording and online analysis.
    • To create a small, autonomous, low-power system capable of handling up to 256 electrodes.
    • To enable real-time computation and data reduction during electrophysiological recordings.

    Main Methods:

    • Utilized a Field Programmable Gate Array System-on-Chip (FPGA SoC) platform for embedded system development.
    • Implemented online detection of biological activity and frequency domain spectral energy analysis across all channels.
    • Integrated microfluidics for controlled substance administration to neural tissue.

    Main Results:

    • The SpikeOnChip platform successfully recorded and analyzed electrophysiological signals from multiple electrodes in real-time.
    • Online detection and spectral analysis identified measurable changes in neuronal activity.
    • Demonstrated the platform's efficacy in an experiment involving bicuculline administration to human neural tissue.

    Conclusions:

    • SpikeOnChip provides a valuable, customizable instrument for neuronal activity recording and analysis.
    • The platform supports automated drug testing and toxicology assessments on human neural models.
    • Programmable hardware and software allow for future extensions and applications.