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Related Experiment Videos

Infectious crystalline keratopathy.

L Remeijer1, G van Rij, C M Mooij

  • 1Eye Hospital, Rotterdam.

Documenta Ophthalmologica. Advances in Ophthalmology
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

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Corticosteroid use can lead to slow-growing, white crystalline opacities in the cornea due to bacterial infections. Treatment for this infectious crystalline keratopathy is challenging, requiring antibiotics and reduced corticosteroid use.

Area of Science:

  • Ophthalmology
  • Microbiology

Background:

  • Corneal opacities can present with varied etiologies.
  • Infectious causes of corneal opacities may not always exhibit significant inflammation.

Observation:

  • Slowly progressive, white, branched crystalline opacities were observed in the corneal stroma of seven patients.
  • Minimal initial inflammatory signs masked the infectious nature of the condition.

Findings:

  • Pathological examination revealed bacterial colonies, primarily gram-positive commensals, within intact corneal lamellae.
  • All affected patients were on regular corticosteroid therapy, often with antibiotics, suggesting an immunosuppressive role.

Implications:

  • Corticosteroid-induced immunosuppression is a likely contributing factor to the development of infectious crystalline keratopathy.

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  • Treatment is complex and prolonged, involving bactericidal antibiotics, minimized corticosteroid dosage, and potentially surgical interventions like partial lamellar keratectomy.