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Updated: Oct 27, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Conventional and Unconventional Approaches for Innovative Drug Treatments in COVID-19: Looking Outside of Plato's

George J Kontoghiorghes1, Annita Kolnagou1, Stella Fetta1

  • 1Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3 Ammochostou Street, Limassol 3021, Cyprus.

International Journal of Molecular Sciences
|July 20, 2021
PubMed

Insights

Researchers are exploring numerous drugs and nutraceuticals to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The goal is to reduce COVID-19 mortality and its global impact.

Area of Science:

  • Pharmacology and Therapeutics
  • Infectious Disease Research

Background:

  • The COVID-19 pandemic caused by SARS-CoV-2 has led to high mortality rates and significant global disruption.
  • Effective therapeutic strategies are urgently needed to manage SARS-CoV-2 infection.

Discussion:

  • Investigating combinations of existing drugs and nutraceuticals offers a promising avenue for therapeutic development.
  • Targeting viral transmission, proliferation, and severe symptoms is crucial for effective treatment.

Key Insights:

  • A wide array of pharmaceutical compounds and nutraceuticals are being evaluated as potential COVID-19 treatments.
  • Combinatorial approaches may enhance therapeutic efficacy against SARS-CoV-2.

Outlook:

  • Further research into drug and nutraceutical combinations could yield novel treatments for COVID-19.
  • Developing targeted therapies is essential to mitigate the severe consequences of SARS-CoV-2 infection.

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