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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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Association of Chronic Liver Disease and Mortality in Patients With Aneurysmal Subarachnoid Hemorrhage

Yu Zhang1, Linjie Li1, Lu Jia1

  • 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China (Y.Z., L.L., L.J., C.Y., Y.C., F.F.).

Stroke
|July 20, 2021
PubMed

Insights

Chronic liver disease (CLD) significantly increases mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). A high Model for End-Stage Liver Disease score further elevates mortality risk in these patients.

Area of Science:

  • Neurology
  • Hepatology
  • Critical Care Medicine

Background:

  • Chronic liver disease (CLD) is a known risk factor for poor outcomes in critically ill patients.
  • The impact of CLD on mortality in aneurysmal subarachnoid hemorrhage (aSAH) patients is not well understood.

Purpose of the Study:

  • To investigate the association between CLD and in-hospital mortality in patients with aSAH.
  • To determine if liver disease severity, using the Model for End-Stage Liver Disease (MELD) score, influences mortality in aSAH patients with CLD.

Main Methods:

  • Retrospective cohort study of 6228 aSAH patients admitted between 2009 and 2019.
  • Propensity score matching was used to compare mortality between aSAH patients with and without CLD.
  • Analysis of the association between MELD score and mortality within the CLD subgroup.

Main Results:

  • A total of 489 (7.9%) aSAH patients had CLD.
  • CLD was significantly associated with increased in-hospital mortality in aSAH patients (OR, 2.04; 95% CI, 1.43–2.92).
  • In aSAH patients with CLD, a higher MELD score correlated with increased mortality risk.

Conclusions:

  • CLD is an independent risk factor for increased mortality in aSAH patients.
  • Liver disease severity, indicated by MELD score, is crucial for predicting outcomes in aSAH patients with CLD.
Abstract

Keywords:
intracranial aneurysmliver diseasesmortalityrisk factorssubarachnoid hemorrhage

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