Related Experiment Video

Updated: Oct 27, 2025

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome
07:38

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome

Published on: August 3, 2021

2.6K

Cessation of smoke exposure improves pediatric CF outcomes: Longitudinal analysis of CF Foundation Patient Registry

Gabriela R Oates1, Elizabeth Baker1, Joseph M Collaco2

  • 1The University of Alabama at Birmingham, Birmingham, AL, United States.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|July 20, 2021
PubMed

Insights

Quitting tobacco smoke exposure significantly improves health outcomes for children and adolescents with cystic fibrosis (CF). Cessation reduces pulmonary exacerbations and enhances respiratory and nutritional status, highlighting the importance of smoke-free environments for CF care.

Area of Science:

  • Pediatric Pulmonology
  • Environmental Health
  • Public Health

Background:

  • Tobacco smoke exposure is a significant health risk for pediatric cystic fibrosis (CF) patients.
  • Assessing the impact of smoke exposure cessation on CF patient outcomes is crucial.

Purpose of the Study:

  • To evaluate the association between cessation of tobacco smoke exposure and improved health outcomes in children and adolescents with CF.
  • To quantify the benefits of smoke exposure cessation on pulmonary exacerbations, lung function (ppFEV1), and body mass index (BMI) in the CF population.

Main Methods:

  • Utilized data from the U.S. CF Foundation Patient Registry (2006-2018) for individuals born 1998-2010.
  • Included participants reporting any history of smoke exposure (second-hand, living with a smoker, or self-smoking).
  • Employed non-linear and linear mixed models to analyze the effects of ceased exposure on pulmonary exacerbations, ppFEV1, and BMI.

Main Results:

  • Cessation of smoke exposure reduced pulmonary exacerbation odds by 17% in the first year, with further 6% reduction per year.
  • Associated with a 0.7% increase in ppFEV1 in the first year, plus 0.4% per year.
  • Led to a 1% increase in BMI percentile in the first year, plus 0.4% per year.
  • Three years of cessation decreased exacerbation probability by 8% and improved ppFEV1 and BMI by 2%.

Conclusions:

  • Eliminating smoke exposure is linked to reduced pulmonary exacerbations and better respiratory and nutritional outcomes in pediatric CF patients.
  • Prioritizing smoking cessation and exposure prevention is essential in managing cystic fibrosis care for children and adolescents.
Abstract

Keywords:
Secondhand smokeSmoke exposureSmoking cessationTobacco

More Related Videos

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

232
The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

9.3K

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
276
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
464
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.6K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.7K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.1K
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
2.8K