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Interleukin-6 as A Prognostic Biomarker in Perinatal Asphyxia
Hassan Boskabadi1, Gholamali Maamouri1, Maryam Zakerihamidi2
1Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Iranian Journal of Child Neurology
|July 20, 2021
Summary
Interleukin-6 (IL-6) levels and hypoxic-ischemic encephalopathy (HIE) grade are key predictors of mortality and developmental outcomes in neonates with prenatal asphyxia. Early diagnosis using these biomarkers improves patient management.
Area of Science:
- Neonatal Medicine
- Biomarkers
- Perinatal Asphyxia
Background:
- Prenatal asphyxia poses significant risks to newborns, necessitating early diagnostic tools.
- Effective management of asphyxia-related complications hinges on accurate prognostic indicators.
Purpose of the Study:
- To assess the prognostic value of Interleukin-6 (IL-6) and Hypoxic-Ischemic Encephalopathy (HIE) grade.
- To predict mortality and developmental status in neonates suffering from prenatal asphyxia.
Main Methods:
- A cohort study involving 38 term asphyxiated infants.
- HIE grading and serum IL-6 levels measured at birth.
- Developmental status assessed using the Denver II test at 2-year follow-up.
Main Results:
- HIE grade 3 was associated with an 83% mortality rate and developmental delay.
- Serum IL-6 levels significantly increased with higher HIE grades (Grade 1: 29 ng/ml, Grade 2: 175 ng/ml, Grade 3: 136 ng/ml).
- An IL-6 cut-off of 24 pg/ml predicted developmental delay with 96% sensitivity and 92% specificity.
Conclusions:
- IL-6 levels and HIE grade serve as valuable prognostic biomarkers.
- These biomarkers aid in determining mortality and morbidity risks in asphyxiated neonates.
