Related Experiment Video
Updated: Oct 27, 2025
08:11
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
8.5K
Syndecan-4 in Tumor Cell Motility
Aniko Keller-Pinter1, Szuzina Gyulai-Nagy1, Daniel Becsky1
1Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Cancers
|July 20, 2021
Summary
Syndecan-4 (SDC4) is a proteoglycan crucial for cell migration and tumor progression. This review summarizes SDC4
Area of Science:
- Cell Biology
- Molecular Biology
- Cancer Research
Background:
- Syndecan-4 (SDC4) is a transmembrane proteoglycan involved in diverse cellular signaling pathways.
- SDC4 links the extracellular matrix to the actin cytoskeleton, influencing cell adhesion, migration, and proliferation.
- Its roles in tumor pathogenesis and progression are increasingly recognized.
Purpose of the Study:
- To summarize the general role of SDC4 in cell migration.
- To review SDC4's involvement in tumor cell motility and progression.
Main Methods:
- Literature review of studies investigating SDC4 expression and signaling in various tumor types.
- Analysis of SDC4's known functions in cell adhesion, migration, and signaling pathways.
Main Results:
- SDC4 regulates cell proliferation and migration by modulating cell-matrix adhesion.
- SDC4 influences key signaling pathways implicated in tumor progression.
- Expression and signaling of SDC4 are critical in several tumor types.
Conclusions:
- SDC4 plays a significant role in promoting tumor cell migration and overall tumor progression.
- Targeting SDC4 may offer therapeutic strategies for cancer treatment.
- Further research into SDC4's specific mechanisms in different cancers is warranted.
Related Concept Videos
01:35Cancer Cell Migration through Invadopodia
2.5K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.5K
01:32Cytoskeletal Coordination in Cell Migration
5.1K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.1K
01:21Chemotaxis and Direction of Cell Migration
3.9K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.9K
01:18Role of Myosin in Cell Migration
2.6K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.6K
01:09Cell Migration
17.5K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.5K
01:19Cell Migration
5.5K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
5.5K