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Viral stimulation modulates endotype-related ACE2 expression in eosinophilic chronic rhinosinusitis

S-N Hong1, J K Kim1, J-A Kim1

  • 1Department of Otorhinolaryngology, Seoul National University College of Medicine, Boramae Medical Center, Seoul, Republic of Korea; Sensory Organ Research Institute, Seoul National University Medical Research Center.

Rhinology
|July 20, 2021
PubMed
Summary

Eosinophilic chronic rhinosinusitis (CRS) shows lower ACE2 expression, but viral stimulation upregulates ACE2 and TMPRSS2 in these tissues. This impacts SARS-CoV-2 entry in CRS patients.

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