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Forming Consensus To Advance Urobiome Research.

Linda Brubaker1, Jean-Philippe F Gourdine2, Nazema Y Siddiqui3

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California, San Diego, San Diego, California, USA.

Msystems
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PubMed
Summary
This summary is machine-generated.

This consensus document provides standardized research practices for urobiome studies. It aims to advance understanding of the urobiome and its role in diseases like kidney disease.

Keywords:
consensusguidelinehuman microbiomeresearchstatementurinary microbiomeurobiome

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Area of Science:

  • Microbiology
  • Urology
  • Genomics

Background:

  • The urobiome, the microbial community in the urinary tract, is increasingly recognized for its role in health and disease.
  • Standardized research methods are crucial for advancing urobiome research and its clinical applications.
  • Current urobiome research lacks consensus on core methodologies, hindering comparability and progress.

Purpose of the Study:

  • To establish a consensus document for standardizing urobiome research practices.
  • To promote common core research methods for specimen handling, metadata collection, and data reporting.
  • To facilitate advancements in understanding the urobiome and its association with diseases.

Main Methods:

  • Development of a consensus document by expert investigators from the UROBIOME 2020 conference.
  • Proposal of standardized nomenclature for urobiome research.
  • Guidelines for specimen collection, preservation, storage, processing, and metadata collection.
  • Recommendations for documenting and reporting urobiome data.

Main Results:

  • A consensus document outlining core research practices for the urobiome.
  • Proposed standardized nomenclature and best practices for study design.
  • Guidelines for data handling and reporting to ensure consistency and reproducibility.
  • Establishment of a foundation for future revisions and advancements in the field.

Conclusions:

  • Standardization of urobiome research methods is essential for scientific progress.
  • Adoption of proposed practices will enhance the reliability and comparability of urobiome studies.
  • This consensus document serves as a foundational guide for the evolving field of urobiome research.