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Related Concept Videos

Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Efficient SARS-CoV-2 Quantitative Reverse Transcriptase PCR Saliva Diagnostic Strategy utilizing Open-Source Pipetting Robots
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Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro.

J Muñoz-Basagoiti1, D Perez-Zsolt1, R León2

  • 1IrsiCaixa AIDS Research Institute, Badalona, Spain.

Journal of Dental Research
|July 20, 2021
PubMed
Summary
This summary is machine-generated.

Oral mouthwashes containing cetylpyridinium chloride (CPC) significantly reduce SARS-CoV-2 infectivity by disrupting viral envelopes and inhibiting cell fusion. This finding suggests CPC mouth rinses may help lower viral transmission from infected individuals.

Keywords:
COVID-19airborne transmissioncellular infectioncoronavirusesoral hygienevirucide

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Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Oral mouthwashes are known to reduce the infectivity of respiratory viruses, including SARS-CoV-2.
  • The specific antiviral agents and mechanisms of action in these rinses are not fully understood.

Purpose of the Study:

  • To identify the active agent in oral mouthwashes with SARS-CoV-2 antiviral activity.
  • To elucidate the mechanism by which this agent reduces viral infectivity.
  • To evaluate the efficacy of CPC-containing mouth rinses against SARS-CoV-2 variants.

Main Methods:

  • Investigated the antiviral activity of cetylpyridinium chloride (CPC), a common mouthwash ingredient.
  • Assessed the effect of CPC on SARS-CoV-2 infectivity in vitro.
  • Examined the mechanism of action, focusing on viral fusion and envelope integrity.
  • Tested efficacy against different SARS-CoV-2 variants and in the presence of saliva.

Main Results:

  • CPC disrupts the viral envelope and inhibits the fusion of SARS-CoV-2 with target cells.
  • CPC-containing mouth rinses reduced SARS-CoV-2 infectivity by over a thousand-fold in vitro.
  • Antiviral activity was observed against various SARS-CoV-2 variants, including the Alpha variant.
  • Efficacy was maintained in the presence of sterilized saliva.

Conclusions:

  • Cetylpyridinium chloride (CPC) is an active agent in oral mouthwashes that effectively reduces SARS-CoV-2 infectivity.
  • CPC acts by disrupting the viral envelope and inhibiting viral fusion.
  • CPC-containing mouth rinses offer a potential cost-effective strategy to decrease SARS-CoV-2 transmission by reducing viral load in saliva.