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Cancer of the penis. Experience at the Norwegian Radium Hospital 1974-1985
S D Fosså1, K S Hall, N B Johannessen
1Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo.
European Urology
|January 1, 1987
Summary
Penile cancer survival is 80% with timely treatment. Sentinel node biopsy aids early detection, and prompt lymph node dissection improves outcomes for patients with positive nodes.
Area of Science:
- Oncology
- Surgical Oncology
- Urologic Oncology
Background:
- Penile cancer presents a significant challenge in urologic oncology.
- Early detection of regional spread is crucial for patient survival.
- Treatment strategies have evolved, impacting long-term outcomes.
Purpose of the Study:
- To evaluate the 5-year survival rates in penile cancer patients.
- To assess the utility of sentinel node biopsy (SLN) in identifying early metastasis.
- To analyze the effectiveness of different treatment modalities, including surgery, radiotherapy, and chemotherapy.
Main Methods:
- Retrospective analysis of 79 penile cancer patients treated between 1974 and 1985.
- Inclusion of data on lymph node status (N0, N1-2, N3).
- Evaluation of sentinel node biopsy (SLN) and radical lymph node dissection outcomes.
Main Results:
- Overall 5-year cancer-specific survival was 80%.
- Sentinel node biopsy (SLN) effectively identifies early regional spread, with favorable outcomes after immediate radical lymph node dissection for N+ patients.
- Tumor-negative SLN did not preclude later metastasis development; however, secondary lymph node dissection cured 5 of 6 relapsing patients.
- Radiotherapy is effective for T1/T2 tumors, necessitating close follow-up for recurrences.
- Combination therapy offers palliative benefits in advanced cases.
Conclusions:
- Sentinel node biopsy (SLN) is valuable for staging penile cancer.
- Prompt surgical intervention, including lymph node dissection, is critical for node-positive patients.
- Multimodal treatment approaches are essential for managing penile cancer effectively, from early-stage to advanced disease.