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Related Concept Videos

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

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Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

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Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
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Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

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It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
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Pharmacovigilance01:19

Pharmacovigilance

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
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Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Advanced Pharmacy Practice Experiences in Pharmacogenomics Offered by US Pharmacy Programs.

Roseann S Gammal1, Jenny Nguyen2, Elaina Audi2

  • 1MCPHS University, School of Pharmacy, Boston, Massachusetts roseann.gammal@mcphs.edu.

American Journal of Pharmaceutical Education
|July 20, 2021
PubMed
Summary

Only 28% of US pharmacy schools offer advanced pharmacy practice experiences (APPEs) focused on pharmacogenomics. These diverse APPEs are led by faculty or non-faculty pharmacists, highlighting a need for more pharmacogenomics education.

Keywords:
APPEexperiential educationpharmacogeneticspharmacogenomics

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Area of Science:

  • Pharmacy Education
  • Pharmacogenomics
  • Experiential Learning

Background:

  • Pharmacogenomics is increasingly important in personalized medicine.
  • Experiential education is crucial for developing pharmacy students' clinical skills.

Purpose of the Study:

  • To characterize the landscape of pharmacogenomics-focused Advanced Pharmacy Practice Experiences (APPEs) in US pharmacy schools.
  • To identify the prevalence, scope, and characteristics of these specialized APPEs.

Main Methods:

  • A cross-sectional, multicenter, observational study surveyed directors of experiential education at accredited US pharmacy schools.
  • Pharmacogenomics APPE preceptors completed an online survey detailing their program offerings.

Main Results:

  • 40% of surveyed schools (28% of total) offered a pharmacogenomics APPE.
  • Thirty unique APPEs were identified, with diverse sites including academic medical centers and testing labs.
  • Each APPE hosted an average of six students annually, with varied activities.

Conclusions:

  • A limited number of US pharmacy schools currently provide dedicated pharmacogenomics APPEs.
  • These APPEs are varied in structure and precepted by both faculty and non-faculty pharmacists.
  • There is a need to expand pharmacogenomics experiential education opportunities for pharmacy students.