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Updated: Oct 27, 2025

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production
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BCR activated CLL B cells use both CR3 (CD11b/CD18) and CR4 (CD11c/CD18) for adhesion while CR4 has a dominant role

Zsuzsa Nagy-Baló1,2, Richárd Kiss3, Judit Demeter4

  • 1Department of Immunology, Eötvös Loránd University, Budapest, Hungary.

Plos One
|July 20, 2021
PubMed

Insights

The study reveals that CD11b and CD11c receptors on chronic lymphocytic leukaemia (CLL) B cells promote disease progression by mediating cell adhesion and migration. These findings explain why CD11c presence worsens CLL prognosis.

Area of Science:

  • Immunology
  • Hematology
  • Cell Biology

Background:

  • Chronic lymphocytic leukaemia (CLL) is the most prevalent leukaemia in Western countries.
  • Previous studies identified CD11b+ or CD11c+ B cells as unfavorable prognostic factors in CLL, but the underlying mechanisms remain unclear.

Purpose of the Study:

  • To investigate the role of CD11b and CD11c in the pathogenesis of CLL.
  • To analyze the involvement of these receptors in B cell adhesion to fibrinogen and migration towards stromal cell-derived factor-1 (SDF-1).

Main Methods:

  • Analysis of CD11b and CD11c expression on CLL B cells.
  • Assays to study B cell adhesion to fibrinogen.
  • Migration assays using SDF-1 as a chemoattractant.
  • Investigation of the CR4 receptor's role in the CD11c+ B cell line BJAB.

Main Results:

  • Both complement receptor 3 (CR3, mediated by CD11b) and CR4 (mediated by CD11c) were found to mediate the adhesion of malignant B cells.
  • CR4 significantly contributed to the migration of leukemic cells towards SDF-1.
  • These receptors are active players in CLL pathogenesis, not just passive markers.

Conclusions:

  • CR3 and CR4 play active roles in chronic lymphocytic leukaemia progression.
  • The findings elucidate how CD11c expression on leukemic B cells can negatively impact CLL prognosis, particularly concerning migration to the bone marrow for survival.

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