Epibulbar Subconjunctival Apocrine Hidrocystoma

Area of Science:

• Ophthalmology
• Dermatology
• Oncology

Background:

• Apocrine hidrocystomas are benign cystic tumors originating from apocrine sweat glands.
• They typically manifest on the head and neck, with ophthalmic cases often near the eyelid margins.

Observation:

• A 57-year-old woman presented with a unique, mobile epibulbar subconjunctival apocrine hidrocystoma.
• The patient had no prior history of ocular trauma or surgery.

Findings:

• Histopathology revealed an empty cyst lined by double-layered cuboidal epithelium.
• The inner epithelial layer showed apical decapitation secretion, confirmed by PAS staining.
• Immunohistochemistry demonstrated positivity for cytokeratin-7, smooth muscle actin, D2-40, and CDGFP-15.

Implications:

• This case expands the known locations of apocrine hidrocystomas within the ocular adnexa.
• Understanding the histopathological and immunohistochemical features is crucial for accurate diagnosis of these rare orbital tumors.