[Effect of propranolol on immunogenesis and its mode of action]

Administration of beta-blocking agent propranolol (1 or 10 mg/kg) 30 and 60 min prior to immunization with sheep red blood cells enhanced the immune response in CBA mice. The activating effect of propranolol upon immunogenesis can be characterized as peripheral since it is preserved after removal of thymus. Beta-adrenergic mechanisms do not participate in immunomodulating action of serotoninergic and dopaminergic systems.