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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Functional connectivity pre-post exercise intervention in individuals with relapsing-remitting multiple sclerosis.

Nazanin Saadat1, Chantel D Mayo1,2, Colleen Lacey1,2

  • 1Department of Psychology.

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Summary

A 12-week walking exercise intervention did not significantly alter global brain network connectivity in multiple sclerosis (MS) patients. Local network changes were mixed, indicating further research is needed to understand exercise

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Medical Imaging

Background:

  • Exercise interventions show promise for managing multiple sclerosis (MS) symptoms.
  • Underlying brain function changes from exercise in MS are not fully understood.
  • A graph theory approach to analyze brain connectivity in MS post-exercise is novel.

Purpose of the Study:

  • To investigate the effects of a speeded walking exercise intervention on functional brain network connectivity in individuals with relapsing-remitting MS (RRMS).
  • To utilize graph theory analyses on resting-state functional MRI (fMRI) data for novel insights.

Main Methods:

  • Acquired resting-state fMRI data from 10 RRMS participants before and after a 12-week speeded walking intervention.
  • Processed fMRI data using DPARSF A version 4.2 and analyzed connectivity with GraphVar2.02.
  • Computed global and local graph theory metrics and used permutation tests to assess pre- to post-intervention differences.

Main Results:

  • No significant changes were observed in global graph theory metrics following the exercise intervention.
  • Local graph theory metrics (clustering coefficient, local efficiency, degree, betweenness centrality) showed mixed results, with both increases and decreases.

Conclusions:

  • A 12-week speeded walking intervention did not yield significant changes in global functional brain network connectivity in RRMS.
  • Local network metric changes were equivocal, suggesting limited impact or need for more sensitive measures.
  • Further research with larger sample sizes and longitudinal designs is necessary to elucidate exercise's neurobiological mechanisms in MS.