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Implementation and implications for polygenic risk scores in healthcare

John L Slunecka1, Matthijs D van der Zee2, Jeffrey J Beck3

  • 1Avera Institute for Human Genetics, Avera McKennan & University Health Center, Sioux Falls, SD, USA. john.slunecka@coyotes.usd.edu.

Human Genomics
|July 21, 2021
PubMed
Summary

Polygenic risk scores (PRSs) use genetic data to predict disease risk, aiding personalized medicine. Challenges include validation, education, integration, and ethical considerations, especially regarding population diversity.

Keywords:
Clinical geneticsGenetic riskPRSPolygenic risk scorePublic healthRisk stratification

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