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Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia.

Jason Smucny1,2, Samuel J Dienel3,4, David A Lewis5,6

  • 1Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, CA, USA.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|July 21, 2021
PubMed
Summary

Schizophrenia (SZ) involves dorsolateral prefrontal cortex (DLPFC) dysfunction, impacting cognitive control and working memory. This study explores how cellular changes in the DLPFC contribute to SZ pathophysiology and cognitive deficits.

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