Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-driven therapeutic antisense oligonucleotide for processing-deficient progeroid laminopathies.

Med (New York, N.Y.)·2026
Same author

Reaching for the cure as progeria research comes of age at the 12th international scientific workshop.

Nature aging·2026
Same author

Efficient prime editing in vivo and in vitro using lipid nanoparticles.

Nature nanotechnology·2026
Same author

AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing.

Nature biotechnology·2026
Same author

Directed evolution of small RNA-stabilizing motifs that improve prime-editing efficiency.

Nature biotechnology·2026
Same author

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 5, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.5K

Base editor treats progeria in mice

Luke W Koblan, Michael R Erdos, Leslie B Gordon

    Nature
    |July 21, 2021
    PubMed
    Summary

    No abstract available in PubMed .

    Keywords:
    CRISPR-Cas9 genome editingDiseasesGenetics

    More Related Videos

    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
    05:48

    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

    Published on: March 16, 2022

    2.8K
    Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
    07:31

    Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

    Published on: February 17, 2023

    1.3K

    Related Experiment Videos

    Last Updated: Jun 5, 2026

    A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
    09:37

    A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

    Published on: July 14, 2016

    8.5K
    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
    05:48

    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

    Published on: March 16, 2022

    2.8K
    Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
    07:31

    Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

    Published on: February 17, 2023

    1.3K