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Related Experiment Video

Updated: Oct 27, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Intraretinal Cysts in Macular Hole: A Structure-Function Correlation Based on En Face Imaging.

Unnikrishnan Nair^1,2, Jay U Sheth^1,2, Asmita Indurkar¹

¹Vitreoretinal Services, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India.

Clinical Ophthalmology (Auckland, N.Z.)

|July 21, 2021

Summary

Macular hole (MH) basal diameter correlates with cyst size, impacting visual outcomes after surgery. Retinal pigment epithelium (RPE) contact loss may explain cyst formation in macular holes.

Keywords:

en face imaging intraretinal cysts macular hole spectral-domain optical coherence tomography

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Last Updated: Oct 27, 2025

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Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

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Published on: August 2, 2013

Area of Science:

Ophthalmology
Retinal Imaging
Surgical Outcomes

Background:

Macular hole (MH) surgery aims to restore visual function.
Understanding micromorphic changes is crucial for predicting surgical success.
En face optical coherence tomography (OCT) offers detailed retinal layer visualization.

Purpose of the Study:

Characterize retinal micromorphic changes using en face OCT in MH surgery.
Determine the role of these changes in MH pathogenesis.
Correlate changes with visual acuity (VA) outcomes post-surgery.

Main Methods:

Retrospective analysis of 28 eyes with successful MH surgery.
Manual segmentation of pre- and post-operative en face OCT scans.
Correlation of MH basal diameter, cyst area (IPL/OPL), and outer retinal defects (EZ/ELM) with VA outcomes.

Main Results:

Significant positive correlation between cyst area (IPL/OPL) and MH basal diameter.
Cyst area was larger in the inner plexiform layer (IPL) than outer plexiform layer (OPL).
Smaller MH diameter, cyst area, and outer retinal defects correlated with better post-operative VA.

Conclusions:

Increased MH basal diameter is linked to enlarged intraretinal cysts (IPL/OPL).
Propose 'RPE contact loss' theory for intraretinal cyst origin due to neurosensory retina detachment.
Micromorphic changes on OCT are key indicators of MH pathogenesis and surgical prognosis.