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The Emerging Role of Circ-SHPRH in Cancer

Xinyue Ju1, Yan Tang1, Rongfeng Qu1

  • 1Department of Hematology and Oncology, The Second Bethune Clinical Medical College of Jilin University, Changchun, Jilin, People's Republic of China.

Oncotargets and Therapy
|July 21, 2021
PubMed
Abstract

Insights

Circular RNA circ-SHPRH acts as a tumor suppressor, inhibiting cancer cell growth and spread. This circular RNA shows promise as a diagnostic and prognostic biomarker for various cancers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are key regulators of gene expression.
  • circ-SHPRH, a specific circRNA, has been implicated in tumorigenesis.
  • Understanding circ-SHPRH's role is crucial for cancer research.

Purpose of the Study:

  • To review the biological characteristics and molecular mechanisms of circ-SHPRH.
  • To explore the clinical significance of circ-SHPRH in various cancers.
  • To evaluate circ-SHPRH as a potential diagnostic and prognostic biomarker.

Main Methods:

  • Analysis of circ-SHPRH expression in multiple tumor types.
  • Review of experimental data on circ-SHPRH's functional roles.
  • Summarization of clinicopathological parameters related to circ-SHPRH.

Main Results:

  • circ-SHPRH upregulation inhibits tumor cell proliferation, migration, and invasion.
  • circ-SHPRH functions as a tumor suppressor across diverse cancers.
  • Evidence supports circ-SHPRH's potential as a biomarker.

Conclusions:

  • circ-SHPRH is a significant tumor suppressor.
  • circ-SHPRH holds potential as a valuable biomarker for cancer diagnosis and prognosis.
Keywords:
SHPRH-146AAbiomarkercancercirc-SHPRH

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