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Published on: January 22, 2013
IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma
Quan Meng1, Can-Xuan Li2, Dan Long3
1Department of Clinical Laboratory, Shenzhen Traditional Chinese Medical Hospital, Shenzhen, Guangdong, People's Republic of China.
Aim:
The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC).
Methods:
Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients' clinicopathological variables and prognosis, and the potential biological mechanisms.
Results:
IQGAP3 was highly expressed in ccRCC and indicated advanced clinical outcome and poor prognosis. IQGAP3 affected the progression of ccRCC through several cancer-related pathways. IQGAP3 might play a vital role in the ccRCC tumor microenvironment.
Conclusion:
IQGAP3 could serve as a promising prognostic biomarker and therapeutic target.
