Related Experiment Video

Updated: Oct 27, 2025

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
11:08

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization

Published on: April 7, 2023

1.2K

Juvenile granulosa cell tumor diagnosed in 6-month-old infant with precocious puberty

Rebecca Hansen1, Austin Lewis2, Christopher Sullivan3

  • 1Department of Radiology, Medical University of South Carolina, Charleston, SC, USA.

Radiology Case Reports
|July 21, 2021
PubMed

Insights

Juvenile granulosa cell tumors are rare ovarian tumors in children, often presenting with precocious puberty. This case highlights a 6-month-old diagnosed with this condition, emphasizing imaging features.

Area of Science:

  • Pediatric Oncology
  • Gynecologic Pathology
  • Diagnostic Imaging

Background:

  • Juvenile granulosa cell tumor (JGCT) is a rare ovarian neoplasm predominantly affecting infants and children.
  • JGCT can manifest with signs of precocious puberty, posing diagnostic challenges in young patients.

Observation:

  • A 6-month-old female presented with clinical signs of precocious puberty.
  • Abdominopelvic imaging demonstrated a large, complex ovarian mass with cystic and solid components, internal enhancement, and restricted diffusion on MRI.

Findings:

  • Surgical exploration confirmed the mass originated from the left ovary.
  • Histopathological examination definitively diagnosed the ovarian mass as a juvenile granulosa cell tumor.

Implications:

  • This case underscores the importance of considering JGCT in the differential diagnosis of precocious puberty in infants.
  • Understanding the characteristic imaging features of JGCT is crucial for accurate preoperative assessment and surgical planning.
  • Further literature review aids in characterizing this rare pediatric tumor.

Keywords:
Juvenile granulosa cell tumorOvarian tumorPrecocious puberty

More Related Videos

A Tissue Culture Model of Estrogen-producing Primary Bovine Granulosa Cells05:36

A Tissue Culture Model of Estrogen-producing Primary Bovine Granulosa Cells

Published on: September 6, 2018

9.4K
A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary07:03

A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary

Published on: September 19, 2025

147

Related Concept Videos

Folliculogenesis01:20

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
1.4K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.3K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
794
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
917
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.7K