Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Miniaturized subcutaneous cellular implants for sustained therapeutic protein delivery in resource-limited settings.

bioRxiv : the preprint server for biology·2026

Same author

HIV, Pregnancy, and Infant Feeding.

JAMA·2026

Same author

Personal PM<sub>2.5</sub>-Bound Metal Exposure Profiles and Their Associations with Inflammatory Biomarkers among Older Adults in Beijing.

Environmental science & technology·2026

Same author

Chitosan-assisted cinnamaldehyde utilization and sodium carboxymethyl cellulose-enabled redispersion: A dual strategy for pathogen-specific grape preservation.

Food chemistry·2026

Same author

PD-L1 expression is associated with inferior outcomes independent of EGFR subtype in advanced non-small cell lung cancer with uncommon EGFR mutations treated with first-line second-generation EGFR-tyrosine kinase inhibitors.

Cancer·2026

Same author

Synthesis of Lithium Iron Phosphate Materials via an All-in-One Integrated Liquid Phase Method.

Molecules (Basel, Switzerland)·2026

Same journal

Shape factor analysis as a quantitative framework for assessing spheroid and organoid morphology and invasiveness.

APL bioengineering·2026

Same journal

HB-EGF enhances collective cell migration via spatial coordination of traction.

APL bioengineering·2026

Same journal

A pump-free microfluidic device for integrated multi-functional testing of tumor spheroids.

APL bioengineering·2026

Same journal

Photobiomodulation outperforms ultrasound in reducing IL-1 <b><i>β</i></b> -driven chondrocyte inflammation.

APL bioengineering·2026

Same journal

Research progress of 3D-printed anti-infective bone tissue engineering scaffolds based on triply periodic minimal surface structures.

APL bioengineering·2026

Same journal

Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.

APL bioengineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

Functional hydrogels for diabetic wound management.

Daqian Gao¹, Yidan Zhang¹, Daniel T Bowers¹

¹Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA.

APL Bioengineering

|July 21, 2021

Summary

This summary is machine-generated.

Multifunctional hydrogels offer a promising strategy for accelerating diabetic wound healing by combating bacterial infections and promoting tissue repair. These advanced materials address complex healing challenges, paving the way for improved patient outcomes.

More Related Videos

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

Related Experiment Videos

Last Updated: Jun 23, 2026

A Simplified Technique for Producing an Ischemic Wound Model

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing Research

Background:

Diabetic wounds exhibit delayed healing and high infection rates due to hyperglycemia, leading to persistent bacterial biofilms.
Complex pathologies including chronic inflammation, oxidative stress, and impaired blood vessel formation hinder effective treatment.

Purpose of the Study:

To review the design, mechanisms, performance, and applications of functional hydrogels for diabetic wound management.
To highlight the potential of multifunctional hydrogels in addressing the multifaceted challenges of diabetic wound healing.

Main Methods:

Systematic review of design strategies for functional hydrogels.
Analysis of hydrogel mechanisms of action, including antibacterial and pro-angiogenic effects.
Evaluation of hydrogel performance and application in accelerating wound healing.

Main Results:

Hydrogels demonstrate unique bactericidal properties and promote wound healing.
Multifunctional hydrogels can simultaneously address bacterial infection, inflammation, and angiogenesis.
Stimuli-responsive hydrogels show significant promise for enhanced therapeutic effects.

Conclusions:

Functional hydrogels represent a promising therapeutic strategy for accelerating diabetic wound healing.
Multifunctional and stimuli-responsive hydrogels are crucial for overcoming the complex pathology of diabetic wounds.
These advanced hydrogels are poised to become a key component in future diabetic wound care.