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Comparison between myocardial function assessed by echocardiography during hospitalization for COVID-19 and at

F M A van den Heuvel1, J L Vos1, B van Bakel2

  • 1Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

The International Journal of Cardiovascular Imaging
|July 21, 2021
PubMed

Insights

COVID-19 recovery may normalize myocardial function, with improved right ventricular size and global longitudinal strain observed post-hospitalization. Cardiac biomarker levels during illness did not correlate with later heart function changes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Echocardiography

Background:

  • Myocardial function changes after COVID-19 hospitalization are not well understood.
  • The relationship between cardiac biomarkers and post-recovery heart function requires investigation.

Purpose of the Study:

  • To assess changes in myocardial function after COVID-19 recovery.
  • To determine if elevated cardiac biomarkers during hospitalization relate to myocardial function changes post-recovery.

Main Methods:

  • Prospective cohort study of hospitalized COVID-19 patients.
  • Transthoracic echocardiography (TTE) performed during hospitalization and at follow-up (median 131 days).
  • Analysis of left ventricular (LV) and right ventricular (RV) function, ejection fraction, tricuspid annular plane systolic excursion, and global longitudinal strain (GLS).

Main Results:

  • No significant differences in LV ejection fraction or tricuspid annular plane systolic excursion between hospitalization and follow-up.
  • Significant reduction in RV diameter and a trend towards improved GLS at follow-up.
  • No correlation found between elevated TroponinT/NT-proBNP during hospitalization and myocardial function at follow-up.

Conclusions:

  • While individual parameters showed no significant change, a trend towards myocardial function normalization was observed post-COVID-19 recovery.
  • Improved GLS at follow-up suggests potential recovery of myocardial function.
  • Elevated cardiac biomarkers during COVID-19 infection did not predict long-term myocardial function deficits.

Keywords:
COVID-19EchocardiographyMyocardial functionSARS-CoV-2

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