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Updated: Oct 27, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Fruit and Vegetable Consumption and the Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
Huaqing Yan1, Xiaobo Cui1, Peng Zhang1
1Department of Urology, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, P.R. China.
Background:
Emerging researches has evaluated whether fruit and vegetable consumption reduce the risk of prostate cancer. However, the conclusions of published articles remained confusing. Thus, we conducted an updated systematic review and meta-analysis to confirm the relationship of fruit and vegetable consumption and the risk of prostate cancer.
Method:
We searched PubMed, EMBASE, Web of Science and Chinese National Knowledge Infrastructure (CNKI) up to September 1, 2020. We finally included 17 cohort studies related to fruit or vegetable intake after rigid quality assessment and checking references of the retrieved articles and relevant reviews. Newcastle-Ottawa scale was adopted to assess the quality of studies and random effect model with RR and 95% CI were used to assess the risk.
Results:
No significant relationship was found between fruit consumption (RR = 1.00, 95% CI = 0.94-1.05) and vegetable consumption (RR = 0.98, 95% CI = 0.94-1.02) and the risk of prostate cancer. No significant heterogeneity or publication bias was identified.
Conclusion:
Our updated meta-analysis demonstrated that fruit and vegetable consumption can barely reduce the risk of prostate cancer with several limitations. Further clinical and basic researches are eagerly awaited to confirm our results and clarify the potential biological mechanisms.
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