Recent applications of asymmetric organocatalytic annulation reactions in natural product synthesis
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Updated: Oct 27, 2025
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Nengzhong Wang1, Zugen Wu, Junjie Wang
1Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore. chmlyx@nus.edu.sg.
Abstract:
The past two decades have witnessed remarkable growth of asymmetric organocatalysis, which is now a firmly established synthetic tool, serving as a powerful platform for the production of chiral molecules. Ring structures are ubiquitous in organic compounds, and, in the context of natural product synthesis, strategic construction of ring motifs is often crucial, fundamentally impacting the eventual fate of the whole synthetic plan. In this review, we provide a comprehensive and updated summary of asymmetric organocatalytic annulation reactions; in particular, the application of these annulation strategies in natural product synthesis will be highlighted.
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