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Association of Hypertension with Severity and Mortality in Hospitalized Patients with COVID-19 in Wuhan, China: A

You-Ping Deng1, Wen Xie2, Tao Liu3

  • 1Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan - China.

Arquivos Brasileiros De Cardiologia
|July 21, 2021
PubMed

Insights

Hypertension is linked to increased severity and mortality in hospitalized COVID-19 patients. Early, aggressive treatment for these patients, particularly for cardiac and kidney issues, is recommended.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to a global pandemic.
  • Understanding comorbidities associated with severe COVID-19 outcomes is crucial for patient management.
  • Hypertension is a prevalent comorbidity with potential implications for COVID-19 prognosis.

Purpose of the Study:

  • To investigate the association between hypertension and the severity and mortality of COVID-19 in hospitalized patients.
  • To identify clinical characteristics and outcomes of COVID-19 patients with and without hypertension.

Main Methods:

  • Retrospective, single-center case study involving 337 hospitalized COVID-19 patients.
  • Data collected from January 20 to February 25, 2020, at the Seventh Hospital of Wuhan City.
  • Statistical analysis performed with a significance level of 0.05.

Main Results:

  • Of 337 patients, 112 (33.2%) had hypertension. Hypertensive patients were older and predominantly male.
  • Hypertension was significantly associated with increased severity (severe/critical cases) and higher mortality rates (17.9% vs. 8.9%).
  • Hypertensive patients exhibited more abnormal laboratory findings, including lymphopenia, inflammation, and impaired cardiac, liver, kidney, and lung function.

Conclusions:

  • Hypertension is a significant risk factor for severe COVID-19 outcomes and mortality.
  • COVID-19 patients with hypertension require vigilant monitoring for cardiac and kidney complications.
  • Aggressive treatment strategies should be considered for hypertensive COVID-19 patients to mitigate adverse outcomes.
Abstract

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