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Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

832

Retraction

    Journal of Cellular Physiology
    |July 21, 2021
    PubMed

    Insights

    This study on Alzheimer's disease is retracted due to data irregularities. The article investigated microRNA-186's effect on neuronal oxidative stress, but image data was found duplicated in other contexts, invalidating the findings.

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Genetics

    Context:

    • Alzheimer's disease (AD) is a neurodegenerative disorder characterized by oxidative stress and neuronal injury.
    • MicroRNAs (miRNAs) play crucial roles in regulating gene expression and cellular processes relevant to AD pathogenesis.
    • The Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is implicated in neuroinflammation and neuronal survival.

    Purpose:

    • To investigate the effect of microRNA-186 (miR-186) on oxidative stress injury in neurons.
    • To explore the potential mechanism involving the targeting of Interleukin-2 (IL-2) via the JAK-STAT pathway.
    • To evaluate these effects in a rat model of Alzheimer's disease.

    Summary:

    • The retracted article proposed that microRNA-186 modulates neuronal oxidative stress in an Alzheimer's disease rat model.
    • It suggested a mechanism where miR-186 targets Interleukin-2, thereby influencing the JAK-STAT signaling pathway.
    • The study aimed to elucidate the role of this specific miRNA in the context of AD-related neuronal damage.

    Impact:

    • The findings, if valid, could have offered insights into novel therapeutic targets for Alzheimer's disease by modulating miRNA and cytokine signaling.
    • Understanding the interplay between miR-186, IL-2, and the JAK-STAT pathway could inform future research directions in neuroprotection.
    • However, the retraction due to duplicated image data invalidates these potential implications and necessitates caution in citing this work.

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