Related Experiment Video

Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

832

Retraction

    Journal of Cellular Physiology
    |July 21, 2021
    PubMed

    Insights

    This study on ovarian cancer metastasis has been retracted due to significant flaws. The findings regarding the CXCL12-CXCR4 axis and AMD3100 are now considered invalid.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cell Biology

    Context:

    • The CXCL12-CXCR4 axis is implicated in ovarian cancer progression.
    • Targeting this axis with AMD3100 was investigated for therapeutic potential.

    Purpose:

    • To evaluate the role of the CXCL12-CXCR4 axis in ovarian cancer metastasis.
    • To assess the efficacy of AMD3100 in inhibiting tumor cell migration and invasion.

    Summary:

    • The article investigated the involvement of the CXCL12-CXCR4 signaling pathway in ovarian cancer metastasis.
    • It explored the potential of blocking this axis with AMD3100 to suppress tumor cell motility.
    • However, the study has been retracted due to identified flaws and inconsistencies.

    Impact:

    • The retraction invalidates previous conclusions regarding the CXCL12-CXCR4 axis in ovarian cancer.
    • This necessitates a re-evaluation of therapeutic strategies targeting this pathway.

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