Related Experiment Video

Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

832

Retraction

    Journal of Cellular Physiology
    |July 21, 2021
    PubMed

    Insights

    This retracted study investigated microRNA-135a's role in rheumatoid arthritis. The findings on the phosphatidylinositol 3-kinase/AKT pathway are now considered invalid due to experimental inconsistencies.

    Area of Science:

    • Molecular Biology
    • Immunology
    • Biochemistry

    Context:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation.
    • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and play roles in various diseases, including RA.
    • The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is crucial in cellular processes and implicated in inflammatory diseases.

    Purpose:

    • To investigate the role of downregulated microRNA-135a (miR-135a) in ameliorating rheumatoid arthritis.
    • To examine the mechanism involving the inactivation of the PI3K/AKT signaling pathway.
    • To identify the involvement of PI3K regulatory subunit 2 (PIK3R2) in this process.

    Summary:

    • The article suggested that reduced levels of miR-135a could alleviate rheumatoid arthritis symptoms.
    • It proposed that this amelioration occurred through the inactivation of the PI3K/AKT signaling pathway.
    • The study indicated that PIK3R2 was a key mediator in this pathway inactivation.

    Impact:

    • The conclusions of this article are considered invalid due to significant flaws and inconsistencies.
    • The retraction highlights the importance of rigorous scientific validation and reproducibility.
    • This retraction impacts the understanding of miR-135a and PI3K/AKT pathway in rheumatoid arthritis research.

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