Related Experiment Video

Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

832

Retraction

    Journal of Cellular Physiology
    |July 21, 2021
    PubMed

    Insights

    This study on microRNA-150 and ischemic stroke has been retracted due to data inconsistencies. The journal found duplicated images, invalidating the findings on neuron survival and the ERK1/2 axis.

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Cell Biology

    Context:

    • Investigated the role of microRNA-150 in ischemic stroke.
    • Focused on its impact on cerebral cortical neuron survival and function.
    • Examined the inhibition of the ERK1/2 signaling pathway.

    Purpose:

    • To elucidate the specific mechanisms by which microRNA-150 influences neuronal outcomes post-stroke.
    • To determine the therapeutic potential of targeting microRNA-150 in stroke treatment.

    Summary:

    • The article suggested microRNA-150 inhibits the ERK1/2 axis via Mal, affecting neuronal survival in ischemic stroke.
    • Allegations of data manipulation led to an investigation by the journal and publisher.
    • Duplicate image findings across different scientific contexts were identified.

    Impact:

    • The findings presented in the article are considered invalid by the editors.
    • This retraction highlights the importance of rigorous data verification in scientific publishing.
    • Undermines previous conclusions regarding microRNA-150's role in ischemic stroke pathology.

    More Related Videos

    Retzius-Sparing Robot-Assisted Radical Prostatectomy12:10

    Retzius-Sparing Robot-Assisted Radical Prostatectomy

    Published on: May 19, 2022

    8.2K
    Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats03:37

    Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats

    Published on: October 11, 2024

    514

    Related Concept Videos

    Clot Retraction and Fibrinolysis01:16

    Clot Retraction and Fibrinolysis

    After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
    7.5K
    Somatic Spinal Reflexes01:22

    Somatic Spinal Reflexes

    Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
    One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
    3.2K
    Cell Motility through Blebbing01:16

    Cell Motility through Blebbing

    Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
    Blebbing Through the Matrix
    In multicellular...
    2.2K
    Relaxation of Skeletal Muscles01:29

    Relaxation of Skeletal Muscles

    The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
    When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
    4.7K
    Types of Membrane Protrusions01:28

    Types of Membrane Protrusions

    The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
    The microvilli, an example of stable protrusions, are finger-like projections...
    3.2K
    GPCR Desensitization01:12

    GPCR Desensitization

    G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
    6.9K