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Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

832

Retraction

    Journal of Cellular Physiology
    |July 21, 2021
    PubMed

    Insights

    This study on breast cancer treatment has been retracted due to significant flaws. The findings regarding large intergenic noncoding RNA-ROR and tamoxifen resistance are now considered invalid.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Context:

    • Endocrine therapy is a cornerstone in breast cancer treatment.
    • Tamoxifen resistance remains a significant clinical challenge, limiting treatment efficacy.
    • Large intergenic noncoding RNAs (lincRNAs) are emerging as critical regulators in cancer progression and drug resistance.

    Purpose:

    • To investigate the inhibitory role of large intergenic noncoding RNA-ROR (lincRNA-ROR) in tamoxifen resistance in breast cancer.
    • To explore the potential mechanism involving the PI3K/Akt/mTOR signaling pathway.

    Summary:

    • The article investigated the role of lincRNA-ROR in tamoxifen resistance in breast cancer.
    • It proposed that lincRNA-ROR regulates the PI3K/Akt/mTOR pathway to influence resistance.
    • However, the study has been retracted due to identified flaws and inconsistencies.

    Impact:

    • The retraction invalidates the previously reported findings on lincRNA-ROR and tamoxifen resistance.
    • This highlights the importance of rigorous scientific validation and reproducibility.
    • Further research is needed to clarify the role of lincRNAs in breast cancer endocrine therapy resistance.

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