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Updated: Oct 27, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

832

Retraction

    Journal of Cellular Physiology
    |July 21, 2021
    PubMed

    Insights

    This retracted study investigated microRNA-21's role in high glucose-induced fibrosis in rat peritoneal mesothelial cells. The findings are invalid due to duplicated image data in the research.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Physiology

    Context:

    • High glucose levels can induce fibrosis in peritoneal mesothelial cells.
    • MicroRNA-21 (miR-21) has been implicated in fibrotic processes.
    • The Ras-MAPK signaling pathway is crucial in cellular responses.

    Purpose:

    • To investigate the role of microRNA-21 in high glucose-induced fibrosis in rat peritoneal mesothelial cells.
    • To determine if microRNA-21 activates the Ras-MAPK signaling pathway via Sprouty-1.

    Summary:

    • The study aimed to elucidate the mechanism by which microRNA-21 contributes to fibrosis under high glucose conditions.
    • It proposed that miR-21 activates the Ras-MAPK pathway through Sprouty-1 in rat peritoneal mesothelial cells.
    • However, the article has been retracted due to duplicated image data.

    Impact:

    • The retraction invalidates the study's conclusions regarding miR-21's role in fibrosis and the Ras-MAPK pathway.
    • This highlights the importance of rigorous data verification in scientific publishing.
    • Researchers should be aware of this retraction when considering the literature on miR-21 and fibrosis.

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