Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

156
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
156
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.8K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Donor-derived airway air-liquid interface model for high-throughput screening of antiviral combinations with concurrent analysis of antiviral efficacy and epithelial toxicity using ciliR.

ERJ open research·2026
Same author

The Platelet/Megakaryocyte Axis is Necessary for Allergic Sensitisation and Inflammatory Responses to House Dust Mite in the Lung.

Lung·2026
Same author

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.

Nature communications·2026
Same author

Ciliated epithelial cell differentiation at air-liquid interface and respiratory syncytial virus infection using animal-free media and substrates.

ERJ open research·2025
Same author

Efficient <i>in vitro</i> assay for evaluating drug efficacy and synergy against emerging SARS-CoV-2 strains.

Antimicrobial agents and chemotherapy·2024
Same author

Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.

Nature·2024
Same journal

Who are you, ketamine? Good, evil, or dose- and context-dependent?

The Journal of physiology·2026
Same journal

Nuances in explaining the blunted erythropoietic response at altitude following recombinant human erythropoietin treatment at sea level.

The Journal of physiology·2026
Same journal

Sex-dependent responses to glucagon agonist therapies in obesity: Mechanistic insights and broader pharmacological implications.

The Journal of physiology·2026
Same journal

Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia.

The Journal of physiology·2026
Same journal

Protein kinase Cδ and pharmacomechanical coupling: Re-envisioning cerebral vascular control.

The Journal of physiology·2026
Same journal

Improved subjective sleep quality in older adults by enhancing the GABAergic system in the sensorimotor cortex.

The Journal of physiology·2026
See all related articles

Related Experiment Video

Updated: Oct 27, 2025

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
09:07

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Published on: January 20, 2017

10.1K

Human models for COVID-19 research.

Maximillian N J Woodall1, Tereza Masonou1, Katie-Marie Case1

  • 1GOS Institute of Child Health, University College London, London, UK.

The Journal of Physiology
|July 21, 2021
PubMed
Summary
This summary is machine-generated.

Developing effective COVID-19 treatments requires physiologically relevant models. This review highlights human challenge models and in vitro systems crucial for understanding disease and testing antiviral drugs.

Keywords:
SARS-CoV-2ciliadifferentitatedinfectionrespiratory

More Related Videos

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.0K
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.1K

Related Experiment Videos

Last Updated: Oct 27, 2025

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
09:07

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

Published on: January 20, 2017

10.1K
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.0K
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.1K

Area of Science:

  • * Virology and Infectious Diseases
  • * Drug Discovery and Development
  • * Human Physiology and Pathology

Background:

  • * Limited therapeutic options currently exist for Coronavirus Disease 2019 (COVID-19).
  • * Understanding disease mechanisms is critical for effective treatment strategies.
  • * Physiologically relevant models are essential for accurate COVID-19 research.

Purpose of the Study:

  • * To review existing human models used in COVID-19 research.
  • * To discuss the utility of these models in antiviral drug development.
  • * To identify key components of disease pathology that can be studied using these models.

Main Methods:

  • * Review of current literature on human models for COVID-19.
  • * Analysis of models including human infection challenge studies.
  • * Evaluation of in vitro systems relevant to airway infections.

Main Results:

  • * Human challenge models offer insights into early infection dynamics.
  • * In vitro systems effectively replicate specific aspects of airway pathology.
  • * Both model types are instrumental in assessing antiviral efficacy.

Conclusions:

  • * Human models are indispensable tools for COVID-19 research and therapeutic evaluation.
  • * Continued development and application of these models will accelerate drug discovery.
  • * These models aid in identifying factors contributing to COVID-19 severity.