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Polymeric Nanoparticles for Transdermal Delivery of Polyphenols.
Namratha Turuvekere Vittala Murthy1, Sagar Kumar Paul1, Harsh Chauhan1
1School of Pharmacy and Health Professionals, Creighton University, Omaha, NE 68178, Nebraska, USA.
Current Drug Delivery
|July 21, 2021
Summary
Polyphenols offer health benefits but face delivery challenges. Polymeric nanoparticles show promise for topical and transdermal delivery of polyphenols, potentially treating skin cancers like melanoma.
Area of Science:
- Natural Products Chemistry
- Nanotechnology
- Dermatology
Background:
- Polyphenols are abundant dietary compounds with significant health benefits.
- Low solubility and bioavailability limit conventional polyphenol delivery and clinical applications.
- Skin cancers, including melanoma, represent a significant health concern.
Purpose of the Study:
- To review the potential of polymeric nanoparticles for polyphenol delivery.
- To evaluate topical and transdermal delivery strategies for polyphenols.
- To explore applications in treating skin cancers like melanoma.
Main Methods:
- Literature review of scientific articles on polyphenols and nanoparticles.
- Analysis of studies on topical and transdermal delivery systems.
- Evaluation of nanoparticle-based polyphenol delivery for skin cancer treatment.
Main Results:
- Polymeric nanoparticles can enhance polyphenol solubility and bioavailability.
- Topical and transdermal delivery systems offer novel routes for polyphenol administration.
- Nanoparticle carriers show potential for targeted delivery in skin cancer therapy.
Conclusions:
- Polymeric nanoparticles are a promising delivery system for polyphenols.
- Topical and transdermal routes can overcome polyphenol bioavailability limitations.
- This approach holds potential for advancing melanoma and other skin cancer treatments.
