Related Experiment Video
Updated: Oct 27, 2025

Implementation of a Coherent Anti-Stokes Raman Scattering CARS System on a Ti:Sapphire and OPO Laser Based Standard Laser Scanning Microscope
Published on: July 17, 2016
Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER
Sergey Korchak1,2, Lukas Kaltschnee1,2, Riza Dervisoglu3
1NMR Signal Enhancement Group, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany.
Abstract:
Nuclear magnetic resonance is usually drastically limited by its intrinsically low sensitivity: Only a few spins contribute to the overall signal. To overcome this limitation, hyperpolarization methods were developed that increase signals several times beyond the normal/thermally polarized signals. The ideal case would be a universal approach that can signal enhance the complete sample of interest in solution to increase detection sensitivity. Here, we introduce a combination of para-hydrogen enhanced magnetic resonance with the phenomenon of the RASER: Large signals of para-hydrogen enhanced molecules interact with the magnetic resonance coil in a way that the signal is spontaneously converted into an in-phase signal. These molecules directly interact with other compounds via dipolar couplings and enhance their signal. We demonstrate that this is not only possible for solvent molecules but also for an amino acid.
Related Concept Videos
Magnetic Resonance Imaging
Atomic Nuclei: Magnetic Resonance
Double Resonance Techniques: Overview
Spin decoupling is usually achieved by...
NMR Spectrometers: Resolution and Error Correction
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences
Atomic Nuclei: Nuclear Relaxation Processes

