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Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection
Lijun Niu1, Lihong Chen2, Yanhua Luo3
1Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University No.58, Zhongshan 2nd Road, Guangzhou, 510080, China.
BMC Anesthesiology
|July 22, 2021
Summary
Oxycodone demonstrated superior analgesic potency compared to morphine following laparoscopic deep infiltrating endometriosis resection. This study found oxycodone to be more effective and have fewer side effects, improving patient recovery after endometriosis surgery.
Area of Science:
- Gynecology
- Pain Management
- Pharmacology
Background:
- Deep infiltrating endometriosis (DIE) resection often involves significant postoperative pain.
- Effective pain management is crucial for patient recovery after laparoscopic DIE surgery.
Purpose of the Study:
- To compare the analgesic potency of oxycodone versus morphine.
- To evaluate the efficacy and side effect profiles of oxycodone and morphine in patients undergoing laparoscopic DIE resection.
Main Methods:
- A randomized controlled trial involving 50 patients undergoing laparoscopic DIE resection.
- Patients received either oxycodone or morphine via intravenous patient-controlled analgesia (PCA).
- Primary outcome: opioid consumption in 24 hours; Secondary outcomes: pain, sedation, nausea, vomiting, and respiratory parameters.
Main Results:
- Oxycodone consumption was significantly lower (14.42 ± 2.83) than morphine (20.14 ± 3.83).
- Patients receiving oxycodone required fewer boluses and had a longer time to first analgesia request.
- Lower incidence of nausea and vomiting observed with oxycodone compared to morphine.
Conclusions:
- Oxycodone is more potent than morphine for analgesia after laparoscopic endometriosis resection.
- Oxycodone offers a favorable side effect profile, including reduced nausea and vomiting, compared to morphine.
- The findings support oxycodone as a potentially preferred analgesic option in this patient population.
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