Comparison of two novel swept-source optical coherence tomography devices to a partial coherence interferometry-based...

Area of Science:

• Ophthalmology
• Biomedical Optics
• Medical Device Technology

Background:

• Accurate ocular biometry is crucial for refractive surgery and intraocular lens (IOL) power calculation.
• Comparing different biometry device technologies, such as swept-source optical coherence tomography (SSOCT) and partial coherence interferometry (PCI), is essential for understanding their clinical applicability.
• Previous studies have highlighted variations in measurement consistency across different devices.

Purpose of the Study:

• To evaluate the repeatability and agreement of corneal and biometry measurements using two SSOCT devices (ANTERION and CASIAII) and one PCI-based device (IOLMaster500).
• To compare the performance of these devices in measuring key ocular parameters including keratometry, central corneal thickness, anterior chamber depth, and axial length.
• To determine if measurements from these devices are interchangeable in clinical practice.

Main Methods:

• A cross-sectional study involving 48 eyes of 48 patients.
• Three consecutive measurements were taken for each eye using ANTERION, CASIAII, and IOLMaster500 during the same visit.
• Measurements included mean keratometry (Km), central corneal thickness (CCT), anterior chamber depth (ACD), and axial length (AL). Corneal astigmatism was analyzed using vector components J0 and J45.
• Intra-device repeatability was assessed using repeatability coefficients (RCs), and inter-device agreement was evaluated using Bland-Altman plots.

Main Results:

• All devices showed comparable repeatability for mean keratometry (Km).
• ANTERION demonstrated the lowest repeatability coefficient for J0 astigmatism.
• Significant systematic differences were observed in Km and J0 between the IOLMaster500 and the SSOCT devices.
• The IOLMaster500 exhibited higher RCs for ACD and AL compared to both SSOCT devices.
• The SSOCT devices showed smaller test-retest variability for ACD and AL measurements compared to the IOLMaster500.
• Significant disagreements were found in keratometry and AL measurements between SSOCT and PCI devices, suggesting they are not interchangeable.

Conclusions:

• Both SSOCT devices (ANTERION and CASIAII) offer superior repeatability for anterior chamber depth and axial length measurements compared to the PCI-based IOLMaster500.
• There are significant measurement discrepancies between SSOCT and PCI technologies for keratometry and axial length.
• Measurements obtained from these different device types should not be considered interchangeable for clinical decision-making, particularly in IOL power calculations.