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Diltiazem counteracts digitalis-dependent splanchnic vasoconstriction in man
1First Medical University Clinic, Division of Clinical Pharmacology, Vienna, Austria.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|October 1, 1987
Summary
Diltiazem reduces digoxin-induced splanchnic vasoconstriction in healthy men. This suggests diltiazem may treat digitalis-related splanchnic vascular insufficiency.
Area of Science:
- Cardiovascular Pharmacology
- Gastrointestinal Physiology
Background:
- Digoxin, a positive inotropic agent, can cause splanchnic vasoconstriction.
- Splanchnic vascular insufficiency can lead to serious complications.
Purpose of the Study:
- To investigate the vasodilating effect of diltiazem on splanchnic and systemic hemodynamics.
- To determine if diltiazem can attenuate digoxin-induced splanchnic vasoconstriction.
Main Methods:
- Twelve healthy men participated in the study.
- Hepatic venous catheter technique, thermodilution, and systolic time intervals were used.
- Diltiazem was administered via infusion, followed by digoxin or saline infusion.
Main Results:
- Diltiazem alone decreased systolic blood pressure but did not affect splanchnic hemodynamics.
- Digoxin increased blood pressure, decreased heart rate, and reduced splanchnic blood flow.
- Concomitant diltiazem infusion prevented digoxin-induced splanchnic vasoconstriction.
Conclusions:
- Diltiazem attenuates digoxin-induced splanchnic vasoconstriction.
- Diltiazem may be beneficial in treating digitalis-dependent splanchnic vascular insufficiency.