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Correlations of circulating miR-26b level with left ventricular hypertrophy and cardiac function in elderly patients

Jian Fu1, Fang Lin2, Zhengxia Pan3

  • 1Jian Fu, Department of Cardiac Surgery, Children's Hospital of Chongqing Medical University, National International Science and Technology Cooperation Base for Children's Developmental Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, P.R. China.

Pakistan Journal of Medical Sciences
|July 22, 2021
PubMed

Insights

Lower levels of miR-26b are linked to left ventricular hypertrophy (LVH) and impaired cardiac function in elderly hypertensive patients. Elevated miR-26b may protect against LVH and diastolic dysfunction.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biomarkers

Background:

  • Hypertension is a major risk factor for cardiovascular diseases, including left ventricular hypertrophy (LVH).
  • LVH is associated with impaired cardiac function and increased risk of heart failure.
  • MicroRNAs (miRNAs) are emerging as key regulators in cardiovascular pathophysiology.

Purpose of the Study:

  • To investigate the association between circulating miR-26b levels and LVH in elderly hypertensive patients.
  • To evaluate the correlation of miR-26b with cardiac function parameters.
  • To determine the diagnostic potential of miR-26b for LVH.

Main Methods:

  • 132 elderly hypertensive patients were categorized into low and high miR-26b groups.
  • Echocardiographic parameters (IVST, LVPWT, LVMI, E/A) and clinical data were analyzed.
  • Pearson correlation, logistic regression, and ROC curve analyses were employed.

Main Results:

  • Low miR-26b levels were significantly associated with increased interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI), and reduced E/A ratio.
  • Circulating miR-26b showed negative correlations with IVST, LVPWT, LVMI, and positive correlation with E/A.
  • Elevated miR-26b was identified as a protective factor against LVH, with an AUC of 0.836 for diagnosis.

Conclusions:

  • Circulating miR-26b levels are inversely correlated with LVH and positively correlated with diastolic function in elderly hypertensive patients.
  • miR-26b may serve as a protective factor against LVH and diastolic dysfunction.
  • miR-26b demonstrates potential as a diagnostic biomarker for LVH in this population.
Abstract

Keywords:
Cardiac functionElderlyHypertensionLeft ventricular hypertrophymiR-26b

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