Related Experiment Video

Updated: Oct 27, 2025

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

2.4K

ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients

David J Hermel1, Samantha R Spierling Bagsic1, Carrie L Costantini1

  • 1Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.

Future Science OA
|July 22, 2021
PubMed

Insights

This study found no link between ABO blood type and COVID-19 severity. However, anemia and male sex were associated with worse COVID-19 outcomes in a diverse patient group.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Epidemiology

Background:

  • COVID-19 severity varies significantly among patient populations.
  • The role of ABO blood phenotype in COVID-19 outcomes requires further investigation.
  • Understanding clinical predictors is crucial for managing severe COVID-19 cases, particularly in diverse demographics.

Purpose of the Study:

  • To investigate the association between ABO blood phenotype and COVID-19 severity.
  • To identify clinical predictors of severe COVID-19 outcomes.
  • To analyze these associations within a predominantly Hispanic population in San Diego County.

Main Methods:

  • Retrospective review of 942 patients hospitalized with COVID-19.
  • Analysis included 473 patients with available blood type data.
  • Multivariate and exploratory analyses were conducted to assess associations.

Main Results:

  • No significant association was identified between ABO blood phenotype and COVID-19 severity (ICU admission, intubation, hospitalization length, death).
  • Anemia diagnosis was significantly associated with all measured COVID-19 severity outcomes.
  • Male sex was also found to be associated with increased COVID-19 severity.

Conclusions:

  • ABO blood phenotype does not appear to be a significant predictor of COVID-19 severity.
  • Anemia and male sex are important clinical correlates of severe COVID-19.
  • These findings contribute to a better understanding of COVID-19 severity factors.
Abstract

Keywords:
ABO blood typeCOVID-19HispanicSan Diegoanemiamale

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

325
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
877
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.7K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.4K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
1.2K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.0K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
547