Counting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative
1Department of Applied Mathematics, University of Washington, Seattle, WA 98195-3925, USA.
Quantitative Biology (Beijing, China)
|July 22, 2021
Abstract:
This tutorial presents a mathematical theory that relates the probability of sample frequencies, of M phenotypes in an isogenic population of N cells, to the probability distribution of the sample mean of a quantitative biomarker, when the N is very large. An analogue to the statistical mechanics of canonical ensemble is discussed.
