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Related Experiment Video

Updated: Oct 27, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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p63 and p53: Collaborative Partners or Dueling Rivals?

Dana L Woodstock1, Morgan A Sammons1, Martin Fischer2

  • 1Department of Biological Sciences, The State University of New York at Albany, Albany, NY, United States.

Frontiers in Cell and Developmental Biology
|July 22, 2021
PubMed
Summary

The tumor suppressor p53 and oncogenic p63 (ΔNp63) proteins have opposing roles in cancer. New research shows these transcription factors can cooperate, challenging the view of their strict rivalry.

Keywords:
oncogenep53p63pioneer factortranscription factortumor suppressor

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Gene Regulation

Background:

  • The p53 and p63 protein families are crucial regulators of cell fate and tumor development.
  • While traditionally viewed as rivals, their complex interplay in oncogenesis requires further elucidation.
  • Both p53 and p63 function as transcription factors, influencing gene expression to control cellular processes.

Purpose of the Study:

  • To re-evaluate the relationship between p53 and its paralog p63 (specifically ΔNp63) in the context of tumor development.
  • To investigate the mechanisms by which p53 and p63 regulate shared and unique target genes.
  • To explore the potential for cooperative functions between p53 and p63, moving beyond a simple adversarial model.

Main Methods:

  • Analysis of transcription factor activity of p53 and ΔNp63.
  • Investigation of pioneer transcription factor roles in chromatin remodeling.
  • Comparative studies of gene targets regulated by both p53 and p63.

Main Results:

  • p53 and ΔNp63 exhibit distinct and overlapping roles in regulating target genes.
  • Both proteins function primarily as transcriptional activators, shifting the paradigm of ΔNp63's function.
  • p53 and p63 act as pioneer transcription factors, influencing chromatin accessibility.
  • Evidence suggests that p53 and p63 can collaborate on gene regulation.

Conclusions:

  • The functional relationship between p53 and p63 is more complex than a simple rivalry.
  • Cooperative interactions between p53 and p63 can occur, influencing cell fate decisions in cancer.
  • Understanding these nuanced interactions provides new insights into therapeutic strategies targeting p53 and p63 pathways.