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Risk Factors of Atrial Arrhythmia in Patients With Liver Cirrhosis: A Retrospective Study

Xiya Lu1, Zhijing Wang1, Liu Yang1

  • 1Division of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Frontiers in Cardiovascular Medicine
|July 22, 2021
PubMed

Insights

Age and ascites are key risk factors for atrial arrhythmia in liver cirrhosis patients. This study identified these factors to improve understanding and management of cardiac complications in liver disease.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Liver cirrhosis is frequently associated with atrial arrhythmias.
  • Specific risk factors for developing atrial arrhythmia in cirrhotic patients are not well-defined.
  • Understanding these risk factors is crucial for managing cardiac complications in liver disease.

Purpose of the Study:

  • To investigate and identify the significant risk factors for atrial arrhythmia in patients diagnosed with liver cirrhosis.
  • To differentiate clinical characteristics associated with atrial arrhythmia in this patient population.

Main Methods:

  • Retrospective analysis of clinical data from 135 liver cirrhosis patients.
  • Data collected from patients admitted to the Department of Gastroenterology at Shanghai Tongji Hospital.
  • Multiple logistic regression analysis employed to identify significant risk factors.

Main Results:

  • Seven factors initially distinguished patients with atrial arrhythmia: age, white blood cell count (WBC), albumin (ALB), serum Na+, B-type natriuretic peptide (BNP), ascites, and Child-Pugh score.
  • Multivariate logistic regression confirmed age (OR=1.098, P=0.001) and ascites (OR=3.874, P=0.023) as significant independent risk factors.
  • Increased age and the presence of ascites were strongly associated with atrial arrhythmia.

Conclusions:

  • Age and ascites are confirmed as significant risk factors for atrial arrhythmia in patients with liver cirrhosis.
  • These findings highlight the importance of monitoring cardiac health, particularly for arrhythmias, in older cirrhotic patients with ascites.
  • Further research may explore targeted interventions based on these identified risk factors.

Keywords:
ageascitesatrial arrhythmialiver cirrhosisrisk factor

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